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2-THIOPHENEGLYOXYLIC ACID | ||
PRODUCT IDENTIFICATION |
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CAS NO. | 4075-59-6 | |
EINECS NO. | 223-794-2 | |
FORMULA | C6H4O3S | |
MOL WT. | 156.16 | |
H.S. CODE |
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TOXICITY |
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SYNONYMS | 2-Thienyl glyoxylic acid; alpha-oxothiophen-2-acetic acid; | |
alpha-oxo-thiophen-2-essigsaeure (German); ácido -alpha-oxotiofen-2-acetico (Spanish); Acide alpha.-oxothiophene-2-acetique (French); | ||
SMILES |
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CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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PHYSICAL STATE | yellow to greenish crystalline powder | |
MELTING POINT | 88 - 91 C | |
BOILING POINT |
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SPECIFIC GRAVITY |
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SOLUBILITY IN WATER | ||
SOLVENT SOLUBILITY |
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pH | ||
VAPOR DENSITY |
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REFRACTIVE INDEX |
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AUTOIGNITION |
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NFPA RATINGS | Health: 3; Flammability: 0; Reactivity: 0 | |
FLASH POINT | ||
STABILITY |
Stable under ordinary conditions. Hygroscopic. | |
APPLICATIONS |
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Glyoxylic acid is the smallest alpha-keto acid which has a ketone group on the
carbon atom next to the acid group. If the ketone group is on the second carbon
next to the acid group, it is called beta-keto acid. Glyoxylic acid has dual
functional compound with both carboxylic acid and aldehyde. One more example of
small mole weight alpha-keto acid is pyruvic acid which has methyl branch. Glyoxylic acid is present in the body as the primary precursor of oxalic acid
and as an intermediate in the conversion of glycolic acid to glycine. The
metabolic pathway to convert fat to carbohydrateby in certain microorganisms and
plants is called glyoxylate cycle. Glyoxylates, any salt, anion, or ester of
glyoxylic acid, are important in biochemical research.
Pure glyoxylic acid is a liquid with melting point of -93 C and boiling Point of 111 C. Glyoxylic acid is formed in commerce by oxidation reaction of glycolic acid or by ozonolysis (oxidaton) and reduction of maleic acid. Ozonolysis which uses ozone is to cleave the alkene bonds. An example of ozonolysis in commerce is the production of odd carbon number carboxylic acids such as azelaic acid and pelargonic acid and simple carboxylic acids such as formic acid and oxalic acid. Allantoin, active in skin-softening (keratolytic effect) and rapid cell regeneration by precipitating proteins on skin is the diureide of glyoxylic acid. In industrial field, it is used as a basic chemical for the synthesis of other chemical products of acids, esters, cyclic compounds. Applications filed includes aroma compounds, agrochemicals, pharmaceuticals, and polymers. Thiophene, also known as thiofuran, is a cyclic compound containing four carbon atoms and one sulfur atom in the ring. Thiophene is an analog to furan and pyrrole where the sulfur atom is replaced by O and NH respectively. Thiophene is a toxic, flammable, and colorless liquid; insoluble in water (soluble in most organic solvents including alcohol and ether); melting at -38 C, boiling at 84 C. Thiophene is the simplest aromatic compound containing sulfur atom and it shares some similar chemical properties with benzene. The lone electron pairs on sulfur in the delocalized pi electron system does not exhibits the properties of thioethers but aromaticity. The sulfur atom is unreactive but the adjacent carbons are susceptible to attack by electrophiles. It is reactive toward sulfonation. In commercial thiophene can be prepared by the reaction of butane and sulfur. Thiophenes are also prepared by the reaction of diketones with Lawesson's reagent. Thiophene and its derivatives exist in petroleum or coal. Thiophene derivatives are also found in natural plant pigments. Biotin, a water-soluble B-complex vitamin, is a reduced thiophene derivative. Thiophene moiety is found in ccphalothin antiboitics. Thiophene is used as a solvent and chemical intermediate. Its derivatives are used in manufacturing dyes, aroma compounds and pharmaceuticals. They are used as monomers to make condensation copolymers. Organic conductive polymers are responsible for the important materials science for the application of polymer electro luminescence. 2-Thiopheneglyoxylic acid is used as an intermediate to manufacture pharmaceuticals, aroma compounds and pesticides. |
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SALES SPECIFICATION | ||
APPEARANCE |
yellow to greenish crystalline powder | |
ASSAY |
95.0% min |
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WATER |
0.5% max |
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TRANSPORTATION | ||
PACKING | 25kgs in carton | |
HAZARD CLASS | 8 (Packing Group: II) | |
UN NO. | 3261 | |
OTHER INFORMATION | ||
Hazard Symbols: C, Risk Phrases: 34, Safety Phrases: 26-27-28-36/37/39-45 | ||
PRICE INFORMATION |
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